【个人简介】

陈如冲，广州医科大学附属第一医院、国家呼吸医学中心、广州呼吸健康研究院呼吸内科教授、主任医师，博士生导师，过敏科行政副主任。担任教育部呼吸健康国际合作联合实验室副主任、呼吸疾病全国重点实验室哮喘与慢咳学组组长、广州国家实验室双聘PI、广东省呼吸健康国际合作基地负责人。

兼任泰晤士高等教育及QS全球大学声誉榜专家组成员、教育部学位论文评审及教学评估专家、国家健康科普专家库成员。兼任中华医学会呼吸病学分会哮喘学组秘书、中国咳嗽联盟委员及秘书、中国预防医学会过敏病专委会常委、广东省呼吸与健康学会过敏专委会主委等。

师从钟南山院士、Paul O’Byrne院士，2007年取得博士学位后，一直致力于支气管哮喘、慢性咳嗽等慢性气道疾病的临床诊治及研究。主持国家实验室专项、国家自然科学基金等纵向基金项目10余项，国际、国内多中心临床试验及IIT研究8项。近五年以第一或通信作者发表SCI论文40余篇，其中在在Lancet子刊、AJRCCM、ERJ、JACI、Allergy、CHEST等中科院1区杂志发表高水平学术论文20余篇（ESI高被引论文4篇，2篇入选ATS、AAAAI的highlight），他引次数20000+。连续四年（2021-2024）入选斯坦福-爱思唯尔全球前2%顶尖科学家榜单。担任ERJ Open Research副主编、Journal of Thoracic Disease编委。执笔或参编支气管哮喘、慢性咳嗽等领域的疾病防控蓝皮书、指南及专家共识多部。

获中国高校十大科技进展、广东省科技进步特等奖、广州市科技进步一等奖、中华医学科技进步三等奖等成果奖励。获全国中青年呼吸精英、广东省杰出青年医学人才、广东省千百十工程培养对象、广州市高层次人才、广州市卫生重点人才、广州市优秀教师、广州市杰出青年岗位能手、羊城抗疫好医生等荣誉称号。

【研究方向】

变应性气道疾病（支气管哮喘与慢性咳嗽）

【科研项目】

1. 国家自然科学基金委员会，面上项目，82470023，IL-23R-STAT-BATF通路介导ILC2转化在柴油车尾气颗粒暴露诱发哮喘加重的作用机制，2025-01至2028-12，48.5万元，在研，主持

2. 广州国家实验室，国家实验室专项（2024年度），GZNL2024A02002，支气管哮喘分子分型及早期诊治研究，2024-01至2028-12，3000万元，在研，主持

3. 广东省自然科学基金委员会，面上项目，2024A1515012894，Tuft细胞IL25-IL17RB-STAT3通路介导区域固有免疫在过敏性哮喘发病中的作用，2024-01至2026-12，15万元，在研，主持

4. 广东省钟南山医学基金会，自主探索课题，ZNSXS-20240007，气道上皮屏障介导FOXA2表达调节哮喘气道黏液分泌的机制研究，2023-01至2025-12，15万元，在研，主持

5. 中华国际医学交流基金会，呼吸疾病青年实用研究项目，Z-2017-24-2301，多模式咳嗽变异性哮喘诊断工具的建立与推广，2024-01至2026-12，30万元，在研，主持

6. 广州市科技局，基础研究计划市校（院）联合资助项目，2024A03J1142， 小胶质细胞活化介导下丘脑旁核可塑性改变在胃食管反流性咳嗽的作用及机制，2024-01至2025-12，36万元，在研，主持

7. 国家自然科学基金委员会，面上项目，82170024，机械敏感性离子通道Piezo1介导NFAT/YAP通路激活在难治性慢性咳嗽中的作用及机制，2022-01至2025-12，54万元，在研，主持

8. 广东省科技厅，国际科技合作基地专项，2021A0505020012，呼吸健康国际联合研究中心，2021-10至2023-04，100万元，已结题，主持

9. 广州市科技局，基础研究计划市校（院）联合资助项目， 202102010349，Piezo2机械敏感阳离子通道在特发性咳嗽发病机制中的作用，2020-11至2022-10，25万元，已结题，主持

10. 国家自然科学基金委员会，面上项目，81870079，ILC2介导嗜酸祖细胞原位分化在柴油车尾气颗粒诱发的嗜酸细胞性支气管炎发病中的作用，2019-01至2022-12，56万元，已结题，主持

【代表性论文及著作】

1. Wenhua Liang^#*, Weijie Guan^#, Ruchong Chen^#, Wei Wang^#, Jianfu Li, Ke Xu, Caichen Li,Qing Ai, Weixiang Lu, Hengrui Liang, Shiyue Li, Jianxing He^*. Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet oncology. 2020,21(3):335-337. (中科院1区, IF=51.1)

2. Tao Wang^#, Ruchong Chen^#, Chunli Liu^#, Wenhua Liang, Weijie Guan, Ruidi Tang, Chunli Tang, Nuofu Zhang, Nanshan Zhong, Shiyue Li^*. Attention should be paid to venous thromboembolism prophylaxis in the management of COVID-19. Lancet Haematology. 2020,7(5):e362-e363. (中科院1区，IF=24.7)

3. Shuxin Zhong, Liman Fang, Zhe Chen, Chen Zhan, S Dushinka de Silva, Kefang Lai^*, Ruchong Chen^*. Noxious Cold Stimulation: Pro-Con Perspectives in effect of Hypothermic on Experimentally Evoked Cough. European respiratory journal,2021,57(3): 2004063. (中科院1区，IF=24.3)

4. Yi Gao^#, Ruchong Chen^#, Qian Geng, Xiaoneng Mo, Chen Zhan, Wenhua Jian, Shiyue Li^*, Jinping Zheng^*. Cardiopulmonary exercise testing might be helpful for interpretation of impaired pulmonary function in recovered COVID-19 patients. European respiratory journal. 2021,57(1):2004265. (中科院1区，IF=24.3)

5. Ruchong Chen, Yi Gao, Mu Chen, Wenhua Jian, Chunliang Lei, Jinping Zheng, Shiyue Li^*. Impaired pulmonary function in discharged patients with COVID-19: more work ahead. European respiratory journal. 2020,56(1):2002194. (中科院1区，IF=24.3)

6. Xiaoneng Mo^#, Wenhua Jian^#, Zhuquan Su^#, Mu Chen, Hui Peng, Ping Peng, Chunliang Lei, Shiyue Li^*, Ruchong Chen^*, Nanshan Zhong^*. Abnormal pulmonary function in COVID-19 patients at time of hospital discharge. European respiratory journal. 2020,55(6):2001217. (中科院1区，IF=24.3)

7. Ziwen Zheng^#, Junfeng Huang^#, Ziyuan Xiang^#, Tong Wu, Xiaoqing Lan, Shuojia Xie, Zikai Lin, Kailun Tang, Alyn Morice, Shiyue Li^*, Woo-Jung Song^*, Ruchong Chen^*. Efficacy and safety of pharmacotherapy for refractory or unexplained chronic cough: a systematic review and network meta-analysis. EClinicalMedicine. 2023 Jul 20;62:102100. (中科院1区，IF=15.1)

8. Haopeng Zhi^#, Xiaolong Ji^#, Zifan Zhao^#, Hanwen Liang^#, Shuxin Zhong^#, Yiting Luo, Mingyu Zhong, Chen Zhan, Yi Gao, Xilong Deng, Shiyue Li, Jing Li^*, Nanshan Zhong^*, Mei Jiang^*, Ruchong Chen^*. Risk factors for impaired pulmonary diffusion function in convalescent COVID-19 patients: A systematic review and meta-analysis. EClinicalMedicine. 2022 Jul;49:101473. (中科院1区，IF=15.1)

9. Mu Chen^#, Jingwei Liu^#, Ping Peng^#, Wenhua Jian^#, Yi Gao^#, Liman Fang^#, Yanhui Yu, Shuxin Zhong, Hui Peng, Xilong Deng, Yuqi Zhou, Sheng Du, Ruchong Chen^*, Xiaoneng Mo^*, Nanshan Zhong^*, Shiyue Li^*. Dynamic changes of pulmonary diffusion capacity in survivors of non-critical COVID-19 during the first six months. EClinicalMedicine. 2022 Jan; 43:101255. (中科院1区，IF=15.1)

10. Yaping Wang^#, Ruchong Chen^#, Fengyu Hu^#, Yun Lan^#, Zhaowei Yang^#, Chen Zhan^#, Jingrong Shi, Xizi Deng, Mei Jiang, Shuxin Zhong, Baolin Liao, Kai Deng, Jingyan Tang, Liliangzi Guo, Mengling Jiang, Qinghong Fan, Meiyu Li, Jinxin Liu, Yaling Shi, Xilong Deng, Xincai Xiao, Min Kang, Yan Li, Weijie Guan, Yimin Li, Shiyue Li, Feng Li, Nanshan Zhong, Xiaoping Tang. Transmission, viral kinetics and clinical characteristics of the emergent SARS-CoV-2 Delta VOC in Guangzhou, China. EClinicalMedicine. 2021 Oct;40:101129. (中科院1区，IF=15.1)

11. Ruchong Chen^#, Ling Sang^#, Mei Jiang^#, Zhaowei Yang^#, Nan Jia^#, Wanyi Fu^#, Jiaxing Xie, Weijie Guan, Wenhua Liang, Zhengyi Ni, Yu Hu, Lei Liu, Hong Shan, Chunliang Lei, Yixiang Peng, Li Wei, Yong Liu, Yahua Hu, Peng Peng, Jianming Wang, Jiyang Liu, Zhong Chen, Gang Li, Zhijian Zheng, Shaoqin Qiu, Jie Luo, Changjiang Ye, Shaoyong Zhu, Jinping Zheng, Nuofu Zhang, Yimin Li, Jianxing He, Jing Li^*, Shiyue Li^*, Nanshan Zhong^*. Longitudinal hematologic and immunologic variations associated with the progression of COVID-19 patients in China. Journal of allergy and clinical immunology. 2020,146(1):89-100. (中科院1区，AAAAI Highlight, editorial choice, IF=14.2)

12. Chen Zhan^#, Jiaxing Liu^#, Bizhou Li^#, Rong Xu, Wanqin Liang, Shengfang Zhang, Liman Fang, Shuxin Zhong, S. Dushinka Shaniya Helen de Silva, Dhinesan Sivapalan, Wei Luo, Hongyu Wang, Jing Li, Kefang Lai, Nanshan Zhong, Roma Sehmi^*, Paul M O’Byrne^*, Ruchong Chen^*. Group 2 Innate Lymphoid Cells in Patients with Non-Asthmatic Eosinophilic Bronchitis. Allergy. 2022 Feb;77(2):649-652. (中科院1区，IF=12.4)

13. Yuheng Liu#, Junfeng Huang#, Shuxin Zhong#, Ziwen Zheng, Zhixing Xu, Dongda Zhou, Shuojia Xie, Zikai Lin, Shiyue Li*, Ruchong Chen*. Efficacy and safety of anti-reflux surgery in gastroesophageal-related cough: a systematic review and meta-analysis. International Journal of Surgery. 2024 Aug 30. doi: 10.1097/JS9.0000000000001998. Online ahead of print. (中科院1区，IF=12.5)

14. Xu Shi^#, Shuxin Zhong^#, Mingyu Zhong^#, Songfeng Chen, Jing Li, Yinglian Xiao^*, Ruchong Chen^*. A 39-year-old man with refractory chronic cough accompanied by regurgitation and belching. Chest. 2024 Jan; 165(1):e11-e17 (中科院1区，IF=10.1)

15. Yonglin Mai^#, Chen Zhan^#, Shengfang Zhang, Jiaxing Liu, Wanqin Liang, Jiawei Cai, Kefang Lai, Nanshan Zhong, Ruchong Chen^*. Arnold Nerve Reflex: Vagal Hypersensitivity in Chronic Cough with Various Causes. Chest, 2020,158(1):264-271. (中科院1区, 同期配发ACCP主席Editorial comment, IF=10.1)

16. Ruchong Chen^#, Wenhua Liang^#, Mei Jiang^#, Weijie Guan^#, Chen Zhan^#, Tao Wang, chunli Tang, Ling Sang, Jiaxing Liu, Zhengyi Ni, Yu Hu, Lei Liu, Hong Shan, Chunliang Lei, Yixiang Peng, Li Wei, Yong Liu, Yahua Hu, Peng Peng, Jianming Wang, Jiyang Liu, Zhong Chen, Gang Li, Zhijian Zheng, Shaoqin Qiu, Jie Luo, Changjiang Ye, Shaoyong Zhu, Xiaoqing Liu, Linling Cheng, Feng Ye, Jinping Zheng, Nuofu Zhang, Yimin Li, Jianxing He, Shiyue Li^*, Nanshan Zhong. Risk factors of fatal outcome in hospitalized subjects with coronavirus disease 2019 from a nationwide analysis in China. Chest, 2020,158(1):97-105. (中科院1区, ESI高被引文章,IF=10.1)

17. Zhangkai J Cheng^#, Bizhou Li^#, Zhiqing Zhan^#, Zifan Zhao^#, Mingshan Xue, Peiyan Zheng, Jiali Lyu, Chundi Hu, Jianxing He^*, Ruchong Chen^*, Baoqing Sun^*. Clinical application of antibody immunity against SARS-CoV-2: comprehensive review on immunoassay and immunotherapy. Clinical reviews in allergy & immunology.2023 Feb;64(1):17-32. (中科院1区，IF=9.1)

18. Tao Wang^#, Chunli Tang^#, Ruchong Chen^#, Honglian Ruan^#, Wenhua Liang, Weijie Guan, Ling Sang, Ruidi Tang, Nanshan Zhong, Shiyue Li^*. Clinical Features of Coronavirus Disease 2019 Patients With Mechanical Ventilation: A Nationwide Study in China. Critical care medicine. 2020,48(9):e809-e812. (中科院1区，IF=8.8)

【所获荣誉和奖励】

1. 2022年荣获上海医学科技进步奖三等奖，胃食管反流性咳嗽规范化诊疗体系的建立和应用；

2. 2021年荣获中华医学科技进步奖三等奖，慢性咳嗽诊治体系的建立；

3. 2021年荣获广东省科技进步奖特等奖，新发冠状病毒感染的防控策略与临床诊治

4. 2013年荣获第六届全国医学优秀多媒体教育软件成果奖三等奖，《支气管哮喘》

5. 2008年荣获广州市科技进步奖一等奖，慢性咳嗽的病因诊断程序、发病机制及其治疗研究