研究生院

陈笛
更新时间:2021-03-25

陈笛,广州医科大学广州霍夫曼免疫研究所副研究员,硕士导师。

研究方向

以果蝇为模型,研究肿瘤免疫识别及反应相关的天然免疫基因以及分子通路

教育经历

2019/8 - 2017/8, Université de Strasbourg,博士后,导师:Jules Hoffmann

2009/1 - 2013/6,University of Western Ontario,Pathology,博士,导师:weiping Min

2005/9 - 2008/6,暨南大学,免疫学,硕士,导师:邢飞跃

2001/9 - 2005/6,华南师范大学,生命科学,学士,导师:王小菁

工作经历

2014/11 -至今,广州医科大学,基础学院,副研究员

主持或参加科研项目及人才计划项目情况

项目类别、批准号、名称、研究起止年月、获资助金额、项目状态(已结题或在研等)、主持或参加。

1.广东省科技计划项目(“海外名师”项目),006012544080、“以果蝇为模型探索天然免疫对原癌细胞的识别以及反应”2019/09/01-2021/08/31、2万元、在研,主持

2.广州市科技计划项目, 201707010030、“髓样来源抑制性细胞促进肝癌细胞干性的分子机制研究” 2017/05/01到2020/04/3、20万元、在研,主持。

3.广东省自然科学基金博士启动项目,2016A030310278、“沉默变异BRAF增加T细胞活性的机制研究”2016/06/01-2019/06/01、10万元、已结题、主持。

4.广州医科大学博士启动项目,20150021、“乳腺癌的RNA干扰免疫疗法:靶向沉默肿瘤相关巨噬细胞的克隆刺激因子受体以及肿瘤坏死因子的表达” 2015/01-2017/12、5万元、已结题、主持。

获奖经历

1.国家留学奖学金2017-2019

2.加拿大健康研究院海报陈述比赛金奖(国家级),2012/06

3.暨南大学研究生奖学金一等奖,2006-2007

3.加拿大健康研究院战略性培训癌症学术研究与实际应用转换项目奖学金,2009/09-2013/04

4.病理学年度研究日最佳基础研究海报陈述奖,2013/04

5.加拿大健康研究院战略性培训癌症学术研究与实际应用转换项目暨肿瘤系年度研究日最佳学术海报陈述奖,2010

发表文章列表

1. Di Chen (#)*, Arghyashree Roychowdhury-Sinha, Pragya Prakash, Xiao Lan, Wenmin Fan, Akira Goto* and Jules A. Hoffmann*. A time course transcriptomic analysis of host and injected oncogenic cells reveals new aspects of Drosophila immune defences. PNAS, 2021, (in press)

2. D Chen(#), J Koropatnick , N Jiang, X Zheng, X Zhang, R Li, King S Siu, A Shunnar, C Way and W Min. Targeted siRNA silencing of IDO in dendritic cells using mannose-conjugated liposomes: a novel strategy for treatment of melanoma. Journal of immunotherapy, 2014, 37(2):123-34.

3. Hua Cai, Andreas Holleufer, Bine Simonsen, Juliette Schneider, Aurélie Lemoine, Hans-Henrik Gad, Jingxian Huang, Jieqing Huang, Di Chen, Tao Peng, João T. Marques, Rune Hartmann, Nelson Martins, Jean-Luc Imler. "2'3'-cGAMP triggers a STING- and NF-kappaB-dependent broad antiviral response in Drosophila." Sci Signal 13(660).

4. King Sun Siu, Di Chen, Xiufen Zheng, Xusheng Zhang, Nathan Johnston, Yanling Liu, Ken Yuan, James Koropatnick, Elizabeth R. Gillies and Wei-Ping Min(*). Single-walled carbon nanotubes non-covalently functionalized with lipid modified polyethylenimine for siRNA delivery in vitro and in vivo. Biomaterials, 2014, 35:3435-3442.

5. Chuqin Huang, Rui Xu, Samuel Liégeois, Di Chen, Zi Li, and Dominique Ferrandon. Differential requirements for Mediator complex subunits in Drosophila melanogaster host defense against fungal and bacterial pathogens. Frontiers Immunology, (in press).

6. Zhou L, Chen D, Huang XM, Long F, Cai H, Yao WX, Chen ZC, Liao ZJ, Deng ZZ, Tan S, Shan YL, Cai W, Wang YG, Yang RH, Jiang N, Peng T, Hong MF, Lu ZQ. Wnt5a Promotes Cortical Neuron Survival by Inhibiting Cell-Cycle Activation. Front Cell Neurosci, 2017,281(11): 1-16.

7. Zheng X(#), Koropatnick J, Chen D, Velenosi T, Ling H, Zhang X, Jiang N, Navarro B, Ichim TE, Urquhart B, Min W(*). Silencing IDO in dendritic cells: a novel approach to enhance cancer immunotherapy in a murine breast cancer model. Int J Cancer, 2013, 132(4):967-77.

8. Cai, H., Yao, W., Huang, J., Xiao, J., Chen, W., Hu, L., Mai, R., Liang, M., Chen, D., Jiang, N., Zhou, L., Peng, T., 2020. Apolipoprotein M, identified as a novel hepatitis C virus (HCV) particle associated protein, contributes to HCV assembly and interacts with E2 protein. Antiviral research 177, 104756.

9. Siu KS(#), Zheng X, Liu Y, Zhang Y, Zhang X, Chen D, Yuan K, Gillies ER, Koropatnick J, Min WP(*). Single-walled carbon nanotubes noncovalently functionalized with lipid modified polyethylenimine for siRNA delivery in vitro and in vivo. Bioconjug Chem, 2014, 25(10):1744-51.

10. Maleki Vareki S(#), Rytelewski M, Figueredo R, Chen D, Ferguson PJ, Vincent M, Min W, Zheng X, Koropatnick J(*). Indoleamine 2,3-dioxygenase mediates immune-independent human tumor cell resistance to olaparib, gamma radiation, and cisplatin. Oncotarget, 2014, 5(9):2778-91.

11. Jiang N(#), Zhang X, Zheng X, Chen D, Siu K, Wang H, Ichim TE, Quan D, McAlister V, Chen G, Min WP(*).A novel in vivo siRNA delivery system specifically targeting liver cells for protection of ConA-induced fulminant hepatitis. PLoS One, 2012, 7(9):e44138.

12. Jiang N(#), Zhang X, Zheng X, Chen D, Zhang Y, Siu LK, Xin HB, Li R, Zhao H, Riordan N, Ichim TE, Quan D, Jevnikar AM, Chen G, Min W(*). Targeted gene silencing of TLR4 using liposomal nanoparticles for preventing liver ischemia reperfusion injury. Am J Transplant. 2011, 11(9):1835-44.

13. Li R(#), Zheng X, Popov I, Zhang X, Wang H, Suzuki M, Necochea-Campion RD, French PW, Chen D, Siu L, Koos D, Inman RD, Min WP(*). Gene silencing of IL-12 in dendritic cells inhibits autoimmune arthritis. J Transl Med, 2012, 10:19.

 
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